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apalutamide will reduce the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which can be CYP3A4 substrates can lead to decrease publicity to these medicines.Insignificant (one)modafinil will increase t